Bringing Precision to Spatial Proteomics

The Naveni™ Proximity Ligation Technology makes it possible to visualize and quantify protein-protein interactions, post-translational modifications, and protein localization.
The technology is based on dual antibody recognition and signal amplification to increase specificity and sensitivity. Today, the technology is applied in three product categories, flexible products, including NaveniFlex and NaveniBright, and target-specific products, including Naveni PTMs.

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Get the precise localization of your target with intact tissue morphology

Correct localization of proteins is critical for understanding and treating many diseases. The quality of in situ protein detection assays depends mainly on the specificity of the antibodies used against the target. Pathologists, e.g., need the whole cell and tissue morphology to confirm cancer cell type and origin of metastatic cancer; that is why enzyme-based chromogenic immunohistochemistry (IHC) of formalin-fixed paraffinized tissues is the “golden standard” for clinical histopathology. But the quality of the IHC method relies largely on single antibodies. Many commercial antibodies have low specificity to the targets, generating unspecific background staining resulting in misleading results. The Naveni™ Proximity Ligation Technology is based on dual antibody recognition, increasing the specificity leading to the correct local precision of the target.