Resources

Instructions and protocols for our products.

Explore comprehensive guides and white papers that offer insights into in situ proximity ligation technology, providing valuable tips and benefits for optimizing its application to meet your unique research needs.

• Powerful background reduction in fluorescent tissue stains for protein-protein interactions using NaveniFlex™ Tissue (PDF)
• NaveniFlex Cell and Tissue application note (PDF)
• Identifying PD-1/PD-L1 interactions (PDF)
• The Naveni® Technology – A Trusted Neuroscience Tool (PDF)
• Troubleshooting guide (PDF)
• The Crucial Role of the CD8-MHC-I Interaction in Cellular Immune Responses (PDF)
• High-throughput fully automated in situ proximity ligation assays for spatial interactomics (PDF)

As a center of excellence in proximity ligation assay, we prioritize research and innovation. To rapidly disseminate our latest findings to the scientific community, we frequently participate in workshops and conferences. Explore our recent collection of scientific posters, highlighting the utility of our Naveni® in situ proximity ligation technology.

2024

SITC 2024

• Assessing differential expression of protein interactions and RNA by combining isPLA and proximal HCR™ Pro RNA-FISH automated assays (PDF) in collaboration with Molecular Instruments
• Fully Automated proximity ligation assay enables high throughput, reproducible detection of protein-protein interactions in tissue for biopharma applications (PDF) in collaboration with Propath UK and Leica Biosystems
• Precision Diagnostics for Immunotherapy Detecting PD1/PD-L1 Interactions in the In Situ Microenvironment of Cancer Tissues (PDF) from our collaborators at Uppsala University
• An integrated approach to high dimensional spatial proteomics and interaction mapping in head and neck cancer tissues prior to immune checkpoint inhibitor therapy (PDF) in collaboration with the University of Queensland
• Utilization of a tissue-based PD1/PD-L1 in situ proximity ligation assay in lung adenocarcinoma LUAD and pleural mesothelioma (PDF) from our collaborators at The University of Texas MD Anderson Cancer Center
• Multiplexed in situ proximity ligation method for identifying functional tumor-immune interactions (PDF)

 

AACR 2024

• Navinci’s 6 Posters Collection (PDF)
• A spatial interactomics approach reveals interplay between the tumor microenvironment and T cell activation (PDF)
• Exploring the role of the MSLN – MUC16 interaction in cancer progression via the in situ proximity ligation technique (PDF)
• isPLA and PhenoCycler integration (PDF)
• Defining PD-1 PD-L1 receptor-ligand interactions in the head and neck cancer tumor microenvironment identifies unique immune cell rivers of cellular interactions (PDF)
• High-resolution analysis of immune checkpoint activation utilizing a combined PD1PD-L1 in situ proximity ligation assay isPLA and multiplex immunofluorescence mIF imaging approach (PDF)
• Integration of High-plex Tumor-immune Phenotyping and Checkpoint Interactions for Deeper Spatial Characterization of Human Cancer Tissues (PDF)
• PD1/PD-L1 interaction as a superior predictor for response to immune checkpoint therapy (PDF)

 

2023

SITC 2023

• Fully automated in situ detection of protein-protein interactions in tissue (PDF)
• Investigating the E-Cadherin B-catenin interaction in colon cancer: a proximity ligation approach (PDF)
• New approaches to understanding the tumor microenvironment: in situ detection of immune checkpoint interactions in cancer patient tissue samples (PDF)

EACR 2023

• Multiplexed proximity ligation-based method uncovers immune checkpoint activation in the context of the tumor microenvironment (PDF)

SCRM 2023

• Multiplexed proximity ligation-based method uncovers immune checkpoint activation in the context of the tumor microenvironment (PDF)

AACR 2023

• In situ detection of various activated immune checkpoints via next-generation proximity ligation assays in tumor tissue (PDF)
• Powerful background reduction in fluorescent tissue stains with an improved proximity-based technology for detection of protein-protein interactions (PDF)
• Naveni TriFlex Cell: An emerging method for simultaneous detection of free proteins and their interactions (PDF)
• Automation of Proximity Ligation Immunoassay for interaction between PD-L1 and PD-1 detection in the tumor microenvironment using microfluidic-based systems (PDF)

CICON 2023

• Unraveling the tumor microenvironment with spatial proteomics: in situ detection of immune checkpoint interactions in cancer patient tissues (PDF)

 

2022

EACR 2022

• Development of a Chromogenic in situ Proximity Ligation Assay for Detection of PD1/SHP2 Proximity in Human FFPE Tissues (PDF)
• Detection of the Proximity of PD1 and PD-L1 in Human FFPE Tissues using a Newly Developed Chromogenic in situ Proximity Ligation Assay (PDF)

Explore comprehensive guides and white papers that offer insights into in situ proximity ligation technology, providing valuable tips and benefits for optimizing its application to meet your unique research needs.

• Naveni pY PD1 (PDF)
• Naveni PD1/PD-L1 (PDF)
• Naveni PD1/PD-L1 Atto647N (PDF)
• NaveniBright (PDF)
• Naveni Triflex Cell (PDF)
• NaveniFlex Cell (PDF)
• NaveniLink (PDF)
• NaveniFlex Tissue (PDF)
• Naveni CD8/MHC-I Atto647N (PDF)
• Naveni PD1/PD-L1 BOND RX HRP (PDF)
• NaveniBright BOND RX HRP (PDF)
• NaveniFlex BOND RX Atto647N/Red (PDF)
• Naveni PD1/PD-L1 BOND RX Atto647N/Red (PDF)

Dive into our webinar series for expert insights, tips, and discussions on the intricacies of protein dynamics and functions.

• Exploring Spatial Interactomics for Deeper Insights into the Tumor Microenvironment
• High throughput detection of protein functional states with Navinci’s in situ proximity ligation assay on the Leica Biosystems BOND RX research stainer

More resources

Go to Publications and Poster Video Presentations.