Resources

White papers exploring in situ proximity ligation assays, detection strategies, and tissue-based applications.

White paper: Identifying PD-1/PD-L1 interactions
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Application notes provide practical guidance and detailed protocols to help you optimize and implement our technologies in your research.

Application note: Powerful background reduction in fluorescent tissue stains for protein-protein interactions using NaveniFlex™ Tissue
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Application note: NaveniFlex Cell and Tissue application note
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Application note: The Naveni® Technology – A Trusted Neuroscience Tool
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Application note: Troubleshooting guide
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Application note: The Crucial Role of the CD8-MHC-I Interaction in Cellular Immune Responses
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Application note: High-throughput fully automated in situ proximity ligation assays for spatial interactomics
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Explore our recent collection of scientific posters, highlighting the utility of our Naveni^® in situ proximity ligation technology.

European Society for Spatial Biology 2026

Poster: A workflow for combined detection of protein interactions and cell types for translational studies (PDF) in collaboration with SciLifeLab and KTH

Poster: Integration of Multiplex isPLA with High-Plex Spatial Phenotyping on the PhenoCycler Fusion (PDF) in collaboration with SciLifeLab and Karolinska Institutet

 

Biomarkers and Precision Medicine UK 2025

Poster: Spatial mapping of proteins and their activity states in cancer models by multiplex isPLA (PDF) 

 

AACR 2025

Poster: Exploring PD1/PD-L1 interactions and macrophage-tumor barriers in head and neck cancer: A spatial approach to immunotherapy response (PDF) in collaboration with University of Queensland

Poster: Development of a novel tri-omic spatial biology assay that provides in-depth immune profiling of the tumor immune microenvironment (PDF) in collaboration with Bruker Spatial Biology and Molecular Instruments

Poster: Multi-plexed spatial interaction analysis of the tumor microenvironment in head and neck cancers (PDF) in collaboration with University of Queensland

Poster: Multiplex in situ proximity ligation assay for functional studies of proteins and their interactions in patient samples (PDF) 

Poster: Comprehensive spatial profiling of the tumor immune microenvironment in triple negative breast cancer from Black women (PDF) in collaboration with Bruker Spatial Biology and St Jude Children’s Research Hospital

 

SITC 2024

Poster: Assessing differential expression of protein interactions and RNA by combining isPLA and proximal HCR™ Pro RNA-FISH automated assays (PDF) in collaboration with Molecular Instruments

Poster: Fully Automated proximity ligation assay enables high throughput, reproducible detection of protein-protein interactions in tissue for biopharma applications (PDF) in collaboration with Propath UK and Leica Biosystems

Poster: Precision Diagnostics for Immunotherapy Detecting PD1/PD-L1 Interactions in the In Situ Microenvironment of Cancer Tissues (PDF) from our collaborators at Uppsala University

Poster: An integrated approach to high dimensional spatial proteomics and interaction mapping in head and neck cancer tissues prior to immune checkpoint inhibitor therapy (PDF) in collaboration with the University of Queensland

Poster: Utilization of a tissue-based PD1/PD-L1 in situ proximity ligation assay in lung adenocarcinoma LUAD and pleural mesothelioma (PDF) from our collaborators at The University of Texas MD Anderson Cancer Center

Poster: Multiplexed in situ proximity ligation method for identifying functional tumor-immune interactions (PDF)

 

AACR 2024

Poster: Navinci’s 6 Posters Collection (PDF)

Poster: A spatial interactomics approach reveals interplay between the tumor microenvironment and T cell activation (PDF)

Poster: Exploring the role of the MSLN – MUC16 interaction in cancer progression via the in situ proximity ligation technique (PDF)

Poster: isPLA and PhenoCycler integration (PDF)

Poster: Defining PD-1 PD-L1 receptor-ligand interactions in the head and neck cancer tumor microenvironment identifies unique immune cell rivers of cellular interactions (PDF)

Poster: High-resolution analysis of immune checkpoint activation utilizing a combined PD1PD-L1 in situ proximity ligation assay isPLA and multiplex immunofluorescence mIF imaging approach (PDF)

Poster: Integration of High-plex Tumor-immune Phenotyping and Checkpoint Interactions for Deeper Spatial Characterization of Human Cancer Tissues (PDF)

Poster: PD1/PD-L1 interaction as a superior predictor for response to immune checkpoint therapy (PDF)

 

SITC 2023

Poster: Fully automated in situ detection of protein-protein interactions in tissue (PDF)

Poster: Investigating the E-Cadherin B-catenin interaction in colon cancer: a proximity ligation approach (PDF)

Poster: New approaches to understanding the tumor microenvironment: in situ detection of immune checkpoint interactions in cancer patient tissue samples (PDF)

 

EACR 2023

Poster: Multiplexed proximity ligation-based method uncovers immune checkpoint activation in the context of the tumor microenvironment (PDF)

 

SCRM 2023

Poster: Multiplexed proximity ligation-based method uncovers immune checkpoint activation in the context of the tumor microenvironment (PDF)

 

AACR 2023

Poster: In situ detection of various activated immune checkpoints via next-generation proximity ligation assays in tumor tissue (PDF)

Poster: Powerful background reduction in fluorescent tissue stains with an improved proximity-based technology for detection of protein-protein interactions (PDF)

Poster: Naveni TriFlex Cell: An emerging method for simultaneous detection of free proteins and their interactions (PDF)

Poster: Automation of Proximity Ligation Immunoassay for interaction between PD-L1 and PD-1 detection in the tumor microenvironment using microfluidic-based systems (PDF)

 

CICON 2023

Poster: Unraveling the tumor microenvironment with spatial proteomics: in situ detection of immune checkpoint interactions in cancer patient tissues (PDF)

 

EACR 2022

Poster: Development of a Chromogenic in situ Proximity Ligation Assay for Detection of PD1/SHP2 Proximity in Human FFPE Tissues (PDF)

Poster: Detection of the Proximity of PD1 and PD-L1 in Human FFPE Tissues using a Newly Developed Chromogenic in situ Proximity Ligation Assay (PDF)

Dive into our webinar series for expert insights, tips, and discussions on the intricacies of protein dynamics and functions.

Webinar: Exploring Spatial Interactomics for Deeper Insights into the Tumor Microenvironment

Webinar: High throughput detection of protein functional states with Navinci’s in situ proximity ligation assay on the Leica Biosystems BOND RX research stainer

Instructions and protocols for discontinued products.

More resources

Go to Publications and Poster Video Presentations.