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PD1/PD-L1 interactions identifies unique immune cell rivers

Dr. Arutha Kulasinghe’s group at University of Queensland performed spatial profiling on Akoya’s Phenocycler Fusion with Navinci’s isPLA technology.

PD1/PD-L1 interactions identifies unique immune cell rivers

Dr. Arutha Kulasinghe’s group at University of Queensland performed spatial profiling on Akoya’s Phenocycler Fusion with Navinci’s isPLA technology.

They combined a 60-plex marker analysis using Akoya’s Phenocycler Fusion with Navinci’s isPLA technology to investigate the PD1/PD-L1 interaction status. Their study revealed that in interaction-positive samples, PD1/PD-L1 interactions were primarily found at the interface between the tumor and the tumor microenvironment (TME), in areas containing both tumor and immune cells, termed “immune cell rivers.”​​​​

They combined a 60-plex marker analysis using Akoya’s Phenocycler Fusion with Navinci’s isPLA technology to investigate the PD1/PD-L1 interaction status. Their study revealed that in interaction-positive samples, PD1/PD-L1 interactions were primarily found at the interface between the tumor and the tumor microenvironment (TME), in areas containing both tumor and immune cells, termed “immune cell rivers.”​​​​

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Defining PD-1/PD-L1 interactions in the tumor microenvironment identifies unique immune cell rivers

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