In partnership with Akoya Biosciences and Navinci, Arutha Kulasinghe’s group at the University of Queensland integrated PD1/PD-L1 isPLA with the PhenoCode Signature Immune Panel to study protein-protein interactions in the broader context of the TME.
High-plex Tumor-immune Phenotyping and Checkpoint Interactions
In partnership with Akoya Biosciences and Navinci, Arutha Kulasinghe’s group at the University of Queensland integrated PD1/PD-L1 isPLA with the PhenoCode Signature Immune Panel to study protein-protein interactions in the broader context of the TME.
After a proof-of-concept study on tonsil tissue, the assay was performed on a head and neck cancer cohort. Using cell segmentation, it was possible to decipher which cells participate in the PD1/PD-L1 interactions and what the isPLA positivity was in different response groups throughout the cohort.
After a proof-of-concept study on tonsil tissue, the assay was performed on a head and neck cancer cohort. Using cell segmentation, it was possible to decipher which cells participate in the PD1/PD-L1 interactions and what the isPLA positivity was in different response groups throughout the cohort.
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