Gain access to cutting edge spatial interactomics
Mapping protein function and networks to better understand health, disease progression and treatment prediction
Naveni® Plex Omni Service
Gain access to cutting edge spatial interactomics
Mapping protein function and networks to better understand health, disease progression and treatment prediction.
Introducing the Naveni® Plex Omni Service – delivering advanced access to spatial interactomics through our proprietary multiplex in situ proximity ligation assay (misPLA) technology, powered by the very experts who created it.
Go deeper into biology
Map protein function and molecular networks directly in spatial context. Detect up to 8 protein–protein interactions, single proteins, or phosphorylation states simultaneously in human FFPE samples – even rare and transient events.
Focus on discovery, not optimization
Our experts guide you from custom panel design to data delivery, providing a seamless process
Answer complex biological questions
Gain new insight into processes that shape health and disease, including:
- Tumor–stroma crosstalk
- Immune cell states and functional phenotypes
- Molecular networks that drive therapy resistance and variable responses to immunotherapy
1
Design your panel
Design your 8-plex in situ multiplex proximity ligation assay panel from a list of pre-validated targets
2
Pre-study consultation
Meet with the Omni Service team to discuss project scope and timelines, and image analysis options
3
Quotation and terms
Receive detailed quotation and terms of service
4
Sample shipment
Using our detailed guidelines, samples will be shipped to Navinci HQ in Uppsala, Sweden
5
Assay run
Next generation multiplex isPLA will be run on your samples by the experts that developed the technology
6
Optional: Image Analysis
If desired, image analysis will be performed by our expert partners at Propath UK
7
Data delivery
Your data will be transferred to you using Pathcore Flow
8
Billing
The project will be concluded and billing will be completed.
Why choose Naveni Plex Omni Service?
Fully custom multiplex panels
Choose freely from 50 verified targets to build a 4-8 plex panel tailored to your research, within a framework that ensures reliability
misPLA performed by the experts
Send your samples and access the world’s first multiplex in situ PLA service, delivering functional insights no kit can match
End-to-end support, zero setup
From consultation to results, our team handles everything – so you can focus on findings, not optimizations
Technology
Understanding protein function in cells and tissues requires improved analytical tools. Our proprietry multiplex in situ proximity ligationa assay (misPLA) employs antibody–oligonucleotide pairs that form amplifiable DNA upon proximal binding, revealing protein interactions and modifications. Up to eight antibody–oligonucleotide pairs enable ligation and rolling circle amplification when target epitopes are nearby.
Pre-validated panels
Can’t decide on a panel? We’ll take care of it.
Instead of designing your own panel, you also have the choice of one of our pre-validated panels, covering key research areas:
MAPK
MAPK panel
The MAPK signaling pathway is a fundamental pathway involved in regulation of cell survival and proliferation. Faulty MAPK-signaling have been linked to development of cancer as well as e.g. Alzheimer’s disease, Parkinsons Disease and Noonan syndrome. With the MAPK-panel we can follow the signaling pathway from activation of EGFR all the way down to phosphorylation of ERK1.
Immuno-oncology
Immuno-oncology panel
PD1-PDL1 is a known immune-checkpoint inhibitor that allows APCs to interact with T-cells without getting attacked. Cancer cells can utilize this system by expressing PDL1 and thereby evade elimination of T-cells. With the IO-panel we can tell a more complete story including the often over looked PD1-PDL2 interaction, downstream events of PD1 in the T-cells as well as what type of T-cell are interacting with the different MHC-classes.
TCR/BCR
TCR/BCR panel
Follow your immune cells in tissues using the TCR/BCR panel that lets you identify different T-cells and their activation status as well as the B-cell maturation and responsiveness.