New publication out!
Wåhlén et al. have just published the article: Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling – ScienceDirect
In the study, they analyzed the co-localization of PDGFR-β and GRB2, PI3K or clathrin, using our Naveni Proximity Ligation Technology. Citation: “For this purpose, NaveniFlex MR (Navinci Diagnostics) was used, which is a more efficient version of in situ PLA”
In the article, they conclude that the different effects of lipid raft disruption on PDGFR-β signaling may provide an opportunity for selective therapeutic targeting of tumor cells.
Could this data support the possibility that cholesterol-lowering drugs, such as statins may impede tumor growth?