Introducing Naveni® Plex: A groundbreaking multiplex in situ proximity ligation assay
Uppsala, Sweden – March 5, 2025 – Navinci is proud to introduce Naveni® Plex, the first multiplex in situ proximity ligation assay (isPLA) with a fluorescent readout, allowing for the simultaneous detection of three separate targets or protein-protein interactions, with unmatched specificity and sensitivity.
As only a minority of patients receiving immune checkpoint inhibition therapy (ICI) respond to treatment, better functional biomarkers to predict and understand response to cancer treatment are urgently needed. A recent study published in the Journal of Thoracic Oncology showed that our assay detecting PD1/PD-L1 interactions can predict more accurately responders versus non-responders compared to currently employed companion diagnostics; in this case, PD-L1 expression by IHC.
Now you can further uncover complex protein interactions in the tumor microenvironment with Naveni® Plex, the groundbreaking isPLA multiplex solution designed to simultaneously detect:
- PD1/PD-L1 interactions – illuminating activated immune checkpoint pathways;
- CD8/MHC-I interactions – revealing initiation of critical T-cell activation processes;
- CD3 presence – tracking a key T-cell marker.
Read more
To find out more about how the Naveni® Plex technology works, see the technology page here.
Ordering Information
To see more information and to order Naveni® Plex, please visit the product page or get in touch with your local distributor.
With Naveni® Plex, researchers can unlock new dimensions in immune-oncology and protein interaction studies, paving the way for the next generation of precision medicine.
For Research Use Only. Not for use in diagnostic procedures.
About Navinci
Navinci is a Swedish biotech company specializing in developing innovative solutions for studying in situ protein expression and interactions. With a focus and a strong legacy in developing in situ proximity ligation assay technology, Navinci has established itself as a center of excellence in the field and has a broad portfolio of products that help researchers study protein interactions in depth.
For more information or for any enquiries, please get in touch.
