Publications

Jensen, N. M., Fu, Y., Betzer, C., Li, H., Elfarrash, S., Shaib, A. H., Krah, D., Vitic, Z., Reimer, L., Gram, H., Buchman, V., Denham, M., Rizzoli, S. O., Halliday, G. M., & Jensen, P. H. (2024). MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity. Npj Parkinson’s Disease, 10(1), 227. https://doi.org/10.1038/s41531-024-00841-9

Naei, V. Y., Tubelleza, R., Monkman, J., Sadeghirad, H., Donovan, M. L., Blick, T., Wicher, A., Bodbin, S., Stad, R., Cooper, C., Barnett, C., O’Byrne, K., Ladwa, R., Warkiani, M. E., Hughes, B. G., & Kulasinghe, A. (2024). Spatial interaction mapping of PD-1/PD-L1 in Head and Neck Cancer reveals the role of Macrophage-Tumour Barriers associated with immunotherapy response. https://doi.org/10.21203/rs.3.rs-5398442/v1

Monti, M., Ferrari, G., Grosso, V., Missale, F., Bugatti, M., Cancila, V., Zini, S., Segala, A., La Via, L., Consoli, F., Orlandi, M., Valerio, A., Tripodo, C., Rossato, M., & Vermi, W. (2024). Impaired activation of plasmacytoid dendritic cells via toll-like receptor 7/9 and STING is mediated by melanoma-derived immunosuppressive cytokines and metabolic drift. Frontiers in Immunology, 14, 1227648. doi.org/10.3389/fimmu.2023.1227648 

Lombardi, Z., Gardini, L., Kashchuk, A. V., Menconi, A., Lulli, M., Tusa, I., Tubita, A., Maresca, L., Stecca, B., Capitanio, M., & Rovida, E. (2024). Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation. Molecular Oncology, 1878-0261.13674. https://doi.org/10.1002/1878-0261.13674

Witowski, A., Palmowski, L., Rahmel, T., Nowak, H., Ehrentraut, S. F., Putensen, C., Von Groote, T., Zarbock, A., Babel, N., Anft, M., Sitek, B., Bracht, T., Bayer, M., Weber, M., Weisheit, C., Pfänder, S., Eisenacher, M., Adamzik, M., Katharina, R., … Zuelch, B. (2024). Activation of the MAPK network provides a survival advantage during the course of COVID-19-induced sepsis: A real-world evidence analysis of a multicenter COVID-19 Sepsis Cohort. Infection. https://doi.org/10.1007/s15010-024-02325-7

Mannion, J., Gifford, V., Bellenie, B., Fernando, W., Ramos Garcia, L., Wilson, R., John, S. W., Udainiya, S., Patin, E. C., Tiu, C., Smith, A., Goicoechea, M., Craxton, A., Moraes De Vasconcelos, N., Guppy, N., Cheung, K.-M. J., Cundy, N. J., Pierrat, O., Brennan, A., Meier, P. (2024). A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death. Immunity,. https://doi.org/10.1016/j.immuni.2024.04.025

Gorji-Bahri, G., Krishna, B. M., Hagerling, C., Orimo, A., Jirström, K., Papadakos, K. S., & Blom, A. M. (2024). Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition. Journal of Translational Medicine, 22(1), 351. https://doi.org/10.1186/s12967-024-05083-0

Arrabal-Gómez, C., Beltran-Casanueva, R., Hernández-García, A., Bayolo-Guanche, J. V., Barbancho-Fernández, M. A., Serrano-Castro, P. J., & Narváez, M. (2024). Enhancing Cognitive Functions and Neuronal Growth through NPY1R Agonist and Ketamine Co-Administration: Evidence for NPY1R-TrkB Heteroreceptor Complexes in Rats. Cells, 13(8), 669. https://doi.org/10.3390/cells13080669

Arrabal-Gómez, C., Serrano-Castro, P., Sánchez-Pérez, J. A., Garcia-Casares, N., Fuxe, K., Borroto-Escuela, D., & Narváez, M. (2024). Potentiation of antidepressant effects: NPY1R agonist and ketamine synergy enhances TrkB signaling and neurogenesis in the ventral hippocampus. Expert Opinion on Therapeutic Targets, 1–14. https://doi.org/10.1080/14728222.2024.2342524

Kulak, K., Kuska, K., Colineau, L., Mckay, M., Maziarz, K., Slaby, J., Blom, A. M., & King, B. C. (2024). Intracellular C3 protects β-cells from IL-1β-driven cytotoxicity via interaction with Fyn-related kinase. Proceedings of the National Academy of Sciences, 121(8), e2312621121. https://doi.org/10.1073/pnas.2312621121

Bandau, S., Alvarez, V., Jiang, H., Graff, S., Sundaramoorthy, R., Gierlinski, M., Toman, M., Owen-Hughes, T., Sidoli, S., Lamond, A., & Alabert, C. (2024). RNA polymerase II promotes the organization of chromatin following DNA replication. EMBO Reports. https://doi.org/10.1038/s44319-024-00085-x

Kastana, P., Ntenekou, D., Mourkogianni, E., Enake, M., Xanthopoulos, A., Choleva, E., Marazioti, A., Nikou, S., Akwii, R. G., Papadaki, E., Gramage, E., Herradón, G., Stathopoulos, G. T., Mikelis, C. M., & Papadimitriou, E. (2023). Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c‐Met to up‐regulate angiogenesis and lung adenocarcinoma growth. International Journal of Cancer, 153(5), 1051–1066. DOI: 10.1002/ijc.34564

Cardoso Dos Santos, L.M., Azar, P., Brun, C. et al. Apelin is expressed in intimal smooth muscle cells and promotes their phenotypic transition. Sci Rep 13, 18736 (2023). DOI:10.1038/s41598-023-45470-z

Hong, J.M., Lee, JW., Seen, DS. et al. LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration. Cell Commun Signal 21, 257 (2023). DOI:10.1186/s12964-023-01261-7

Vitet Hélène, Bruyère Julie, Xu, Hao, Séris Claire, Brocard Jacques, et al. (2023) loHuntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning. Cambridge: eLife Sciences Publications Ltd. DOI:10.7554/eLife.81011

Gustav Godtliebsen, Kenneth Bowitz Larsen, Zambarlal Bhujabal, Ida S. Opstad, Mireia Nager, Abhinanda R. Punnakkal, Trine B. Kalstad, Randi Olsen, Trine Lund, Dilip K. Prasad, Krishna Agarwal, Truls Myrmel & Asa Birna Birgisdottir (2023) High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts, Autophagy, DOI: 10.1080/15548627.2023.2230837

Heinzl, N., Maritschnegg, E., Koziel, K. et al. Amyloid-like p53 as prognostic biomarker in serous ovarian cancer—a study of the OVCAD consortium. Oncogene 42, 2473–2484 (2023). DOI:10.1038/s41388-023-02758-8

Ilana B. Kotliar^‡, Emilie Ceraudo^‡, Kwvin Kemelmakher-Liben, Deena A. Oren, Emily Lorenzen, Tea Dodig-Crnković, Mizuho Horioka-Duplix, Thomas Huber, Jochen M. Schwenk, Thomas P. Sakmar. Itch receptor MRGPRX4 interacts with the receptor activity–modifying proteins. Journal of Biological Chemistry, Volume 299, May 2023, DOI:10.1016/j.jbc.2023.104664.

Martino Avallone¹, Joaquin Pardo^1,2, Tadiwos F. Mergiya^3,4, Jana Rájová¹, Atte Räsänen¹, Marcus Davidsson¹, Main Åkerblom¹, Luis Quintino⁵, Darshan Kumar⁶, Clive R. Bramham^3,4, Tomas Björklund^1*(2023). Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling. Front. Mol. Neurosci. 16:1140785. DOI:10.3389/fnmol.2023.1140785.

Erik Wåhlén, Frida Olsson, Doroteya Raykova, Ola Söderberg, Johan Heldin¹, Johan Lennartsson¹ Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion Biochemical and Biophysical Research Communications, volume 665, May 2023, DOI:10.1016/j.bbrc.2023.04.099.

Madeleine Ross, Elias Aizenman GluA1-Shank3 interaction decreases in response to chronic neuronal depolarization Neuroscience Letters, 2023, 137305, ISSN 0304-3940, DOI:10.1016/j.neulet.2023.137305

Camille Ternet^{1 2}, Philipp Junk^{1 2}, Thomas Sevrin^{1 2}, Simona Catozzi^{1 2}, Erik Wåhlén³, Johan Heldin³, Giorgio Oliviero¹, Kieran Wynne^{1 4}, Christina Kiel^{5 1 2} Analysis of context-specific KRAS-effector (sub)complexes in Caco-2 cells Life Sci Alliance. 2023 Mar 9;6(5):e202201670, DOI:10.26508/lsa.202201670

Alegre-Martí et al. A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance Science Advances. 9, eade2175. Mar 2023, DOI: 10.1126/sciadv.ade2175

Estela Díaz-Sánchez ^a b, Alexander López-Salas ^a, Marina Mirchandani-Duque ^a, Jose Erik Alvarez-Contino ^a, Jose Andrés Sánchez-Pérez ^c, Kjell Fuxe ^d, Dasiel O. Borroto-Escuela ^a d e, Natalia García-Casares ^a, Manuel Narváez ^a b d .Decreased medial prefrontal cortex activity related to impaired novel object preference task performance following GALR2 and Y1R agonists intranasal infusion. Biomedicine & Pharmacotherapy. Volume 161, May 2023, 114433. DOI: 10.1016/j.biopha.2023.114433

Han Gyung Kim¹, Nak Yoon Sung², Ji Hye Kim¹, Jae Youlho³. In vitro Anti-cancer effects of beauvericin through inhibition of actin polymerization and Src phosphorylation Phytomedicine Jan;109:154573., DOI:10.1016/j.phymed.2022.154573

Mathieu Cinato et al. Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility, Life Science Alliance January 2023, DOI: 10.26508/lsa.202201690

Ilana B. Kotliar, Emily Lorenzen, Jochen M. Schwenk, Debbie L. Hay and Thomas P. Sakmar. Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins. Pharmacological Reviews January 2023, 75 (1) 1-34; DOI: 10.1124/pharmrev.120.000180

Katri Vaparanta, Anne Jokilammi, Mahlet Tamirat, Johannes A. M. Merilahti, Kari Salokas, Markku Varjosalo, Johanna Ivaska, Mark S. Johnson & Klaus Elenius An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation. Nature Communications volume 13, Article number: 6953 (2022). https://www.nature.com/articles/s41467-022-34539-4#Sec2

Lisa M. Røst, Synnøve B. Ræder, Camilla Olaisen, Caroline K. Søgaard, Animesh Sharma, Per Bruheim & Marit Otterlei PCNA regulates primary metabolism by scaffolding metabolic enzymes. Oncogene (2022). https://pubmed.ncbi.nlm.nih.gov/36564470/

Konstantinos S. Papadakos, Alexander Ekström, Piotr Slipek, Eleni Skourti, Steven Reid, Kristian Pietras & Anna M. Blom Sushi domain-containing protein 4 binds to epithelial growth factor receptor and initiates autophagy in an EGFR phosphorylation independent manner. Journal of Experimental & Clinical Cancer Research volume 41, Article number: 363 (2022). https://pubmed.ncbi.nlm.nih.gov/36578014/

Yo Han Hong. et al. The EEF1AKMT3/MAP2K7/TP53 axis suppresses tumor invasiveness and metastasis in gastric cancer, Cancer letter 2022  https://pubmed.ncbi.nlm.nih.gov/35753528/

Athanasios S. Alexandris, Jiwon Ryu, Labchan Rajbhandari, Robert Harlan, James McKenney, Yiqing Wang, Susan Aja, David Graham, Arun Venkatesan, Vassilis E. Koliatsos. Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons, Neurobiology of Disease, Volume 171, 2022, DOI:10.1016/j.nbd.2022.10580

Zimmerli D. et al. TBX3 acts as tissue-specific component of the Wnt-beta cathenin transcriptional complex. eLife 2020;9:e58123

Alice J L Zheng, Aikaterini Thermou, Chrysoula Daskalogianni, Laurence Malbert-Colas, Konstantinos Karakostis, Ronan Le Sénéchal, Van Trang Dinh, Maria C Tovar Fernandez, Sébastien Apcher, Sa Chen, Marc Blondel, Robin Fahraeus, The nascent polypeptide-associated complex (NAC) controls translation initiation in cis by recruiting nucleolin to the encoding mRNA, Nucleic Acids Research, 2022;, gkac751, DOI:10.1093/nar/gkac751

Erik Wåhlén, Frida Olsson, Ola Söderberg, Johan Lennartsson, Johan Heldin. Differential impact of lipid raft depletion on platelet-derived growth factor (PDGF)-induced ERK1/2 MAP-kinase, SRC and AKT signaling, DOI:10.1016/j.cellsig.2022.110356

Klaesson A, Grannas K, Ebai T, Heldin J, Koos B, Leino M, Raykova D, Oelrich J, Arngården L, Söderberg O, Landegren U. Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes. Sci Rep. 2018 Mar 29;8(1):5400. PMID: 29599435

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