A collaborative effort between Navinci and Molecular Instruments explored how the Molecular Instruments HCR™ Pro RNA-FISH can be combined with the Navinci isPLA, and then be fully automated on the BOND RX by Leica Biosystems.
Assessing differential expression of protein interactions and RNA by combining isPLA and HCR™ Pro RNA-FISH automated assays
A collaborative effort between Navinci and Molecular Instruments explored how the Molecular Instruments HCR™ Pro RNA-FISH can be combined with the Navinci isPLA, and then be fully automated on the BOND RX by Leica Biosystems.
Navinci and Molecular Instruments present a combined HCR™ Pro RNA-ISH and isPLA assay, enabling precise co-detection of RNA transcripts and protein-protein interactions within the same tissue sample. The assay supports both single and dual-plex RNA-ISH, in this example targeting PPIB and then PD1 and PD-L1, providing deeper biological insights. This integration allows simultaneous analysis of multiple RNA molecules and protein interactions, conserving time and valuable samples. The scalable, high-performance approach is particularly beneficial but not limited to immuno-oncology, advancing biomarker studies and therapeutic discoveries by linking RNA expression to functional protein interactions.
Navinci and Molecular Instruments present a combined HCR™ Pro RNA-ISH and isPLA assay, enabling precise co-detection of RNA transcripts and protein-protein interactions within the same tissue sample. The assay supports both single and dual-plex RNA-ISH, in this example targeting PPIB and then PD1 and PD-L1, providing deeper biological insights. This integration allows simultaneous analysis of multiple RNA molecules and protein interactions, conserving time and valuable samples. The scalable, high-performance approach is particularly beneficial but not limited to immuno-oncology, advancing biomarker studies and therapeutic discoveries by linking RNA expression to functional protein interactions.
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